Transition Metal‐Free Cycloisomerization of Propargylic Amides to Oxazoles in Hexafluoroisopropanol (HFIP)
نویسندگان
چکیده
A transition metal-free method for the cycloisomerization of propargylic amides to oxazoles was developed. The reaction utilizes in situ generated hydrogen chloride hexafluoroisopropanol (HFIP). With aid Design Experiments optimization a wide range substrates transformed into desired oxazoles. allows product formation without side reactions eliminating need extensive work-up and purification.
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ژورنال
عنوان ژورنال: Advanced Synthesis & Catalysis
سال: 2022
ISSN: ['1615-4169', '1615-4150']
DOI: https://doi.org/10.1002/adsc.202200559